Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Cough
ADR ID BADD_A01105
ADR Hierarchy
22      Respiratory, thoracic and mediastinal disorders
22.02      Respiratory disorders NEC
22.02.03      Coughing and associated symptoms
22.02.03.001      Cough
Description A disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound. [CTCAE] A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs. [MeSH]
MedDRA Code 10011224
MeSH ID D003371
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Cough | Cough increased | Cough nonproductive | Cough resembling asthma | Coughing | Dry cough | Irritant cough | Irritative cough | Nocturnal cough | Persistent dry cough | Persistent non-productive cough | Cough aggravated | Coughing after drug inhalation | Drug-induced cough | Smoker's cough | Paroxysmal cough | Acute cough | Chronic cough | Persistent cough | Painful cough | Cough ineffective | Cough weak | Coughs
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
B2 bradykinin receptorP30411T23714
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02473Sodium chloride0.003926%
BADD_D02476Polyethylene glycol0.000334%
BADD_D02477Tenofovir alafenamide0.006510%
BADD_D02480Alectinib0.001332%
BADD_D02483Ribociclib0.005062%
BADD_D02486Niraparib0.006394%
BADD_D02487Baricitinib0.005211%
BADD_D02489Neratinib--
BADD_D02492Deflazacort0.003891%
BADD_D02495Duvelisib0.001066%
BADD_D02498Abemaciclib--
BADD_D02500Alpelisib--
BADD_D02503Telotristat ethyl--
BADD_D02504Lorlatinib--
BADD_D02509Brigatinib0.004529%
BADD_D02510Rucaparib0.014120%
BADD_D02511Siponimod--
BADD_D02514Etelcalcetide--
BADD_D02515Pexidartinib0.001066%
BADD_D02517Enasidenib--
BADD_D02518Semaglutide--
BADD_D02520Baloxavir marboxil--
BADD_D02522Lithium citrate--
BADD_D02523Hydrocortisone succinate0.005742%
BADD_D02524Ivosidenib0.000799%
BADD_D02526Larotrectinib0.000533%
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